Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.

@article{Premkumar1995InductionOH,
  title={Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.},
  author={Daniel R Premkumar and Mark A. Smith and Peggy L. Richey and Robert Bob Petersen and Roberto Castellani and Rahul Krishnan Kutty and Barbara N Wiggert and George Perry and Raj N Kalaria},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 3},
  pages={
          1399-402
        }
}
Previous studies demonstrated the specific association of heme oxygenase (HO)-1 protein to the neurofibrillary pathology of Alzheimer's disease (AD). In this study, we used reverse transcription-polymerase chain reaction methods to show the increased expression of HO-1 but not HO-2 mRNA transcripts in cerebral cortex and cerebral vessels from subjects with AD compared with age-matched non-AD controls. Neither the HO-1 nor the HO-2 mRNA levels was altered in the cerebellum, a brain region… CONTINUE READING
Highly Cited
This paper has 120 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Selegiline increases heme oxygenase-1 expression and the cytotoxicity produced by dopamine treatment of neuroblastoma SK-N-SH cells.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2004
View 6 Excerpts
Highly Influenced

120 Citations

0510'98'03'09'15
Citations per Year
Semantic Scholar estimates that this publication has 120 citations based on the available data.

See our FAQ for additional information.