Induction of heme oxygenase‑1 expression protects articular chondrocytes against cilostazol‑induced cellular senescence.

Abstract

Chondrocyte senescence is associated with the aging and degeneration of cartilage, and eventually leads to joint destruction. The aim of this study was to elucidate the mechanisms responsible for the cytoprotective effects of heme oxygenase‑1 (HO‑1) on chondrocytes in cartilage. Chondrocyte senescence was induced using cilostazol and measured using a… (More)
DOI: 10.3892/ijmm.2014.1918

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