Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury.

@article{Villar1993InductionOH,
  title={Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury.},
  author={Jes{\'u}s Monterrubio Villar and J D Edelson and Martin Post and J Brendan M Mullen and Arthur S Slutsky},
  journal={The American review of respiratory disease},
  year={1993},
  volume={147 1},
  pages={177-81}
}
This study examined the hypothesis that transient, whole-body hyperthermia would reduce lung damage and/or mortality in a previously described animal model of acute lung injury. Normal, adult Sprague-Dawley rats were randomly assigned either to a heated (n = 40) or to a sham-heated (n = 49) group. Heated animals were warmed to 41 to 42 degrees C 18 h before intratracheal instillation of phospholipase A2. Forty-eight hours after phospholipase A2 exposure, the two groups were compared in a… CONTINUE READING
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