Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury.

@article{Villar1993InductionOH,
  title={Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury.},
  author={J. N{\'u}{\~n}ez Villar and Johnathan Edelson and Martin Franciscus Maria Post and James B. Mullen and Arthur S Slutsky},
  journal={The American review of respiratory disease},
  year={1993},
  volume={147 1},
  pages={
          177-81
        }
}
This study examined the hypothesis that transient, whole-body hyperthermia would reduce lung damage and/or mortality in a previously described animal model of acute lung injury. Normal, adult Sprague-Dawley rats were randomly assigned either to a heated (n = 40) or to a sham-heated (n = 49) group. Heated animals were warmed to 41 to 42 degrees C 18 h before intratracheal instillation of phospholipase A2. Forty-eight hours after phospholipase A2 exposure, the two groups were compared in a… CONTINUE READING
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An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.

  • American journal of respiratory cell and molecular biology
  • 2011
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Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms.

  • American journal of respiratory cell and molecular biology
  • 2012
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