Induction of heat shock proteins may combat insulin resistance.

  title={Induction of heat shock proteins may combat insulin resistance.},
  author={Mark Frederick McCarty},
  journal={Medical hypotheses},
  volume={66 3},
The molecular mechanism responsible for obesity-associated insulin resistance has been partially clarified: increased fatty acid levels in muscle fibers promote diacylglycerol synthesis, which activates certain isoforms of protein kinase C (PKC). This in turn triggers a kinase cascade which activates both IkappaB kinase-beta (IKK-beta) and c-Jun N-terminal kinase (JNK), each of which can phosphorylate a key serine residue in IRS-1, rendering it a poor substrate for the activated insulin… CONTINUE READING


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