Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys after ischemia.

  title={Induction of heat-shock proteins HSP73 and HSP90 in rat kidneys after ischemia.},
  author={Kiyozo Morita and Hideki Wakui and Atsushi Komatsuda and Hiroshi Ohtani and Akira B. Miura and Hiroshi Itoh and Yohtalou Tashima},
  journal={Renal failure},
  volume={17 4},
We examined rat kidneys for serial expressions of two major heat-shock proteins (HSPs), HSP73 and HSP90, after 60 min of unilateral renal ischemia up to day 28. Immunohistochemical studies showed that HSP73 and HSP90 were rapidly induced in the cytoplasm of injured epithelial cells of the S3 segment of proximal tubules and were again induced in the cytoplasm of regenerative cells in this segment from day 3. In epithelial cells of the Henle's loops, HSP90 was also induced in the cytoplasm of… CONTINUE READING

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