Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065.

@article{Zsido1991InductionOH,
  title={Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065.},
  author={T J Zsido and Jan M. Woynarowski and Raymond M. Baker and Loretta S Gawron and Terry A. Beerman},
  journal={Biochemistry},
  year={1991},
  volume={30 15},
  pages={3733-8}
}
CC-1065 is a very potent antitumor antibiotic capable of covalent and noncovalent binding to the minor groove of naked DNA. Upon thermal treatment, covalent adducts formed between CC-1065 and DNA generate strand breaks [Reynolds, R. L., Molineux, I. J., Kaplan, D.J., Swenson, D.H., & Hurley, L.H. (1985) Biochemistry 24, 6228-6237]. We have shown that this molecular damage can be detected following CC-1065 treatment of mammalian whole cells. Using alkaline sucrose gradient analysis, we observe… CONTINUE READING

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