Induction of growth arrest by miR-542-3p that targets survivin.

Abstract

Survivin is a protein which functions as a mitotic regulator as well as apoptosis inhibitor. In this study, we show that introduction of synthetic miR-542-3p mimetic reduced both mRNA and protein levels of survivin. In A549 cells, luciferase reporter assay revealed that miR-542-3p targeted predicted binding sites in the 3'-untranslated region (3'-UTR) of… (More)
DOI: 10.1016/j.febslet.2010.08.025

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