Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury.

@article{Ou1997InductionOG,
  title={Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury.},
  author={Ying C Ou and Stephen M. Thompson and Steffen Kirchner and Terrance J Kavanagh and Elaine M. Faustman},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={147 1},
  pages={31-8}
}
Methylmercury (MeHg) is recognized as a significant environmental hazard, particularly to the development of the nervous system. Studies on the mechanism of MeHg-induced toxicity reveal that inhibition of cell cycle progression may be one way by which MeHg interferes with normal development. In this study, we utilized primary rodent embryonic neuronal cell (CNS) and limb bud (LB) cultures to determine the mRNA expression level of two genes involved in cell cycle arrest, Gadd45 and Gadd153, both… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS