Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1.

@article{Hogg2009InductionOG,
  title={Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1.},
  author={Alison Elizabeth Hogg and Gavin C. Bowick and Norbert K. Herzog and Miles W. Cloyd and Janice J. Endsley},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 5},
  pages={1191-203}
}
Immunosuppression following infection with HIV-1 predisposes patients to a myriad of opportunistic pathogens, one of the most important of which is Mtb. Granulysin, expressed by NK cells and CTL, exhibits potent antimicrobial activity against Mtb and several other opportunistic pathogens associated with HIV-1 infection. The immune signals that promote… CONTINUE READING