Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?

@article{Sriram2004InductionOG,
  title={Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?},
  author={Krishnan Sriram and Stanley Anthony Benkovic and Meleik A Hebert and Diane Bemis Miller and James P O'Callaghan},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 19},
  pages={19936-47}
}
Reactive gliosis is a hallmark of disease-, trauma-, and chemical-induced damage to the central nervous system. The signaling pathways associated with this response to neural injury remain to be elucidated, but recent evidence implicates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. Here, we used the known dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to selectively damage striatal dopaminergic nerve terminals and… CONTINUE READING

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Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Reactive gliosis is a hallmark of disease- , trauma- , and chemical - induced damage to the central nervous system .
Nerve EndingsSibling in is aNeuroglia
Here , we used the known dopaminergic neurotoxicant , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) , to selectively damage striatal dopaminergic nerve terminals and elicit a glial response .
NeurogliaSibling in is aNerve Endings
Here , we used the known dopaminergic neurotoxicant , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) , to selectively damage striatal dopaminergic nerve terminals and elicit a glial response .
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