Induction of globin mRNA expression by interleukin-3 in a stem cell factor-dependent SV-40 T-antigen-immortalized multipotent hematopoietic cell line.

@article{Cairns2003InductionOG,
  title={Induction of globin mRNA expression by interleukin-3 in a stem cell factor-dependent SV-40 T-antigen-immortalized multipotent hematopoietic cell line.},
  author={Linda A. Cairns and Marco Cir{\'o} and Mario Minuzzo and François Morl{\'e} and Jo{\"e}lle Starck and Sergio Ottolenghi and Antonella Ellena Ronchi},
  journal={Journal of cellular physiology},
  year={2003},
  volume={195 1},
  pages={
          38-49
        }
}
Erythropoiesis requires the stepwise action on immature progenitors of several growth factors, including stem cell factor (SCF), interleukin 3 (IL-3), and erythropoietin (Epo). Epo is required to sustain proliferation and survival of committed progenitors and might further modulate the level of expression of several erythroid genes, including globin genes. Here we report a new SCF-dependent immortalized mouse progenitor cell line (GATA-1 ts SCF) that can also grow in either Epo or IL-3 as the… CONTINUE READING
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