Induction of genomic instability and activation of autophagy in artificial human aneuploid cells.

@article{Ariyoshi2016InductionOG,
  title={Induction of genomic instability and activation of autophagy in artificial human aneuploid cells.},
  author={Kentaro Ariyoshi and Tomisato Miura and Kosuke Kasai and Yohei Fujishima and Mitsuo Oshimura and Mitsuaki Yoshida},
  journal={Mutation research},
  year={2016},
  volume={790},
  pages={19-30}
}
Chromosome missegregation can lead to a change in chromosome number known as aneuploidy. Although aneuploidy is a known hallmark of cancer cells, the various mechanisms by which altered gene and/or DNA copy number facilitate tumorigenesis remain unclear. To understand the effect of aneuploidy occurring in non-tumorigenic human breast epithelial cells, we… CONTINUE READING