Induction of gene expression by 5-Aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms

@article{Schmelz2005InductionOG,
  title={Induction of gene expression by 5-Aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms},
  author={Karin Schmelz and Nicole Sattler and M Wagner and Michael Luebbert and Bernd Doerken and Ingo Tamm},
  journal={Leukemia},
  year={2005},
  volume={19},
  pages={103-111}
}
The methylation inhibitor 5-Aza-2′-deoxycytidine (5-Aza-CdR, decitabine) has therapeutic efficacy in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Using microarray analysis, we investigated global changes in gene expression after 5-Aza-CdR treatment in AML. In the AML cell line OCI-AML2, Aza-CdR induced the expression of 81 out of 22 000 genes; 96 genes were downregulated (⩾2-fold change in expression). RT-PCR analysis of 10 randomly selected genes confirmed the changes of… CONTINUE READING
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