Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins.

@article{ElHizawi2002InductionOG,
  title={Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins.},
  author={Sally El-Hizawi and James P Lagowski and Molly Kulesz-Martin and Amador Albor},
  journal={Cancer research},
  year={2002},
  volume={62 11},
  pages={
          3264-70
        }
}
Gene amplification accompanies tumor progression and is involved in the development of drug resistance. Previously, we reported (A. Albor et al., Cancer Res. 58: 2091-2094, 1998) that mutant p53 proteins conserve the capacity to interact with and activate topoisomerase I, and that this could be a mechanism for induction of genomic instability by mutant p53 proteins. To test this hypothesis, the effect of exogenous mutant p53 protein expression on genomic instability in human p53-/- Saos-2 cells… CONTINUE READING

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References

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SHOWING 1-10 OF 65 REFERENCES

Gain of function mutations in p53

  • Nature Genetics
  • 1993
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Gain-of-function mutations in the tumor suppressor gene p53.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
VIEW 2 EXCERPTS