Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

@article{Smaele2001InductionOG,
  title={Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.},
  author={Enrico De Smaele and Francesca Zazzeroni and Salvatore Papa and Dung U. Nguyen and Rongguan Jin and Joy Maria Jones and Rong Cong and Guido Franzoso},
  journal={Nature},
  year={2001},
  volume={414 6861},
  pages={
          308-13
        }
}
In addition to coordinating immune and inflammatory responses, NF-kappaB/Rel transcription factors control cell survival. Normally, NF-kappaB dimers are sequestered in the cytoplasm by binding to inhibitory IkappaB proteins, and can be activated rapidly by signals that induce the sequential phosphorylation and proteolysis of IkappaBs. Activation of NF-kappaB antagonizes apoptosis or programmed cell death by numerous triggers, including the ligand engagement of 'death receptors' such as tumour… CONTINUE READING

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