Induction of fusion-competent myoblast-specific gene expression during myogenic differentiation of Drosophila Schneider cells by DNA double-strand breaks or replication inhibition.

@article{Hossain2005InductionOF,
  title={Induction of fusion-competent myoblast-specific gene expression during myogenic differentiation of Drosophila Schneider cells by DNA double-strand breaks or replication inhibition.},
  author={Muktadir Shahid Hossain and Kenji Kurokawa and Kazuhisa Sekimizu},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1743 1-2},
  pages={176-86}
}
Differentiation of Drosophila Schneider cells caused by DNA double-strand break (DSB)-inducing topoisomerase II (topo II) inhibitors were attenuated by ICRF-193, a non-DNA-damaging topo II inhibitor. ICRF-193 did not inhibit differentiation induced by neocarzinostatin (NCS), a drug that causes DNA DSBs independent of topo II. Schneider cells differentiated… CONTINUE READING