Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde.

@article{VanderVeen2003InductionOF,
  title={Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde.},
  author={Laurie A. VanderVeen and Muhammed F Hashim and Yu Shyr and Lawrence J Marnett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 24},
  pages={14247-52}
}
Instability of repetitive sequences is a hallmark of human cancer, and its enhancement has been linked to oxidative stress. Malondialdehyde is an endogenous product of oxidative stress that reacts with guanine to form the exocyclic adduct, pyrimido[1,2- alpha]purin-10(3H)-one (M1G). We used site-specifically modified single- and double-stranded vectors to investigate the mutagenic potential of M1G in bacteria and mammalian cells. M1G induced frameshift mutations (-1 and -2) when positioned in a… CONTINUE READING
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