Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells.

@article{BraleyMullen1985InductionOE,
  title={Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells.},
  author={Helen Braley-Mullen and Marjorie Johnson and Gordon C. Sharp and Michael Kyriakos},
  journal={Cellular immunology},
  year={1985},
  volume={93 1},
  pages={132-43}
}
Spleen cells from CBA/J or SJL mice sensitized with mouse thyroglobulin (MTg) and lipopolysaccharide (LPS) could be activated in vitro with MTg to transfer experimental autoimmune thyroiditis (EAT) to normal syngeneic recipients. EAT induced by these transferred cells was similar in incidence and severity to EAT induced by active immunization of mice with MTg and adjuvant and cells from EAT-resistant Balb/c mice could not be activated to induce EAT. The specific antigen MTg was required both… CONTINUE READING

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