Induction of estrogen receptor-alpha and -beta activities by synthetic progestins.

  title={Induction of estrogen receptor-alpha and -beta activities by synthetic progestins.},
  author={Thomas Rabe and Michael K Bohlmann and S Rehberger-Schneider and Sophia Prifti},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  volume={14 2},
The cellular action of steroid hormones is mediated by specific receptors. Recently, two different estrogen receptors (ER), alpha and beta, have been cloned with a specific tissue distribution. Active estrogen as well as active progestin are compounds of oral hormonal contraceptives and hormone replacement therapy. To examine the regulation of ER-alpha and -beta activities after treatment with synthetic progestins and synthetic and natural estrogens, COS 7 cells were transfected with the vector… CONTINUE READING

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