Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

@article{Montesano1991InductionOE,
  title={Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors},
  author={Roberto Montesano and Gerhard Schaller and Lelio Orci},
  journal={Cell},
  year={1991},
  volume={66},
  pages={697-711}
}
Branching morphogenesis of human mammary epithelial cells in collagen gels.
TLDR
The results suggest that the modulation of alpha 3 beta 1 activity may represent an important event in the induction of branching morphogenesis of human mammary epithelial cells.
Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells.
TLDR
It is demonstrated that hepatocyte growth factor promotes the formation of branching duct-like structures by mammary gland epithelial cells in vitro, and suggested that it may act as a mediator of the inducing effect of mesenchyme (or stroma) on mammary glands development.
Hepatocyte growth factor and Madin‐Darby canine kidney cells: In vitro models of epithelial cell movement and morphogenesis
  • D. Balkovetz
  • Biology, Medicine
    Microscopy research and technique
  • 1998
TLDR
In vitro models of MDCK cells exposed to HGF will continue to be useful in the study of epithelial cell movement and morphogenesis in vitro and will provide important clues into the cellular mechanisms important during in vivo epithelial processes such as organ development, regeneration, and transformation to carcinoma.
Morphogenesis of MDCK cells in a collagen gel matrix culture under stromal adipocyte-epithelial cell interaction.
TLDR
Results indicate that the specific stromal cell type adipocytes cause MDCK cells to organize the well-polarized tubular structures in two different manners according to their direct and indirect interactions, suggesting that adipocytes may be involved in the regulatory mechanism of renal epithelial morphogenesis.
Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts.
TLDR
Preliminary evidence suggests that the factor(s) in Swiss 3T3 conditioned medium that induces tubule formation by endothelial cells may be different from a number of well-characterized angiogenic cytokines.
Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells
TLDR
Evidence is provided that, at low concentrations, TGF-beta-1 promotes MMP-dependent branching tubulogenesis by mammary epithelial cells in vitro, and that it plays a similar role during mammary gland development in vivo.
Factors affecting morphogenesis of rabbit gallbladder epithelial cells cultured in collagen gels
TLDR
The results suggest that the morphogenetic program of Rabbit gallbladder epithelial cells is likely to be determined by the interaction of these peptides and the timing of their presence.
Role of fibronectin deposition in branching morphogenesis of Madin-Darby canine kidney cells.
TLDR
Results indicate that the deposition of fibronectin underlying the tubule-lining epithelium serves to enhance cell proliferation and migration, and hence facilitates the branching tubulogenesis of MDCK cells.
An in vitro tubule assay identifies HGF as a morphogen for the formation of seminiferous tubules in the postnatal mouse testis.
TLDR
It is confirmed that laminin and collagen IV are essential for the formation of testicular cords and reveal that HGF/c-met are necessary for the further remodeling of these cords into tubules.
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Two cell lines--Madin-Darby canine kidney (MDCK) and normal murine mammary gland (NMuMG)--growing as monolayers on collagen gels were overlaid with another collagen gel. The cells responded to the
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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
TLDR
The scatter factor is a paracrine effector of epithelial-mesenchymal interaction, which affects the intercellular connections and mobility of normal epithelial cells, and might be involved in epithelial migration.
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TLDR
Collagen‐gel‐cultured MDCK cysts provide an easily manipulable in vitro cell system that may offer unique advantages for the study of renal cell structure and function.
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