Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.

  title={Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin.},
  author={Yao Ding and Kirill Gelfenbeyn and Leonardo Freire-de-Lima and Kazuko Handa and Sen-itiroh Hakomori},
  journal={FEBS letters},
  volume={586 13},
Epithelial-mesenchymal transition (EMT) has been shown to play a key role in embryogenesis and cancer progression. We previously found that fibronectin (FN) carrying O-GalNAc at a specific site is selectively expressed in cancer and fetal cells/tissues, and termed oncofetal FN (onfFN). Here, we show that (i) a newly-established monoclonal antibody against FN lacking the O-GalNAc, termed normalFN (norFN), is useful for isolation of onfFN, (ii) onfFN, but not norFN, can induce EMT in human lung… CONTINUE READING

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