Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.

@article{Hackett2009InductionOE,
  title={Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.},
  author={Tillie L. Hackett and Stephanie Mary Warner and Dorota Stefanowicz and Furquan Shaheen and Dmitri V. Pechkovsky and Lynne A. Murray and Rochelle L. Argentieri and Anthony Kicic and Stephen M Stick and Tony R. Bai and Darryl A Knight},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={180 2},
  pages={122-33}
}
RATIONALE Airway remodeling in asthma is associated with the accumulation of fibroblasts, the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal transition (EMT) may play a significant role. OBJECTIVES To evaluate whether EMT occurs in primary airway epithelial cells (AECs), the mechanisms involved, and if this process is altered in asthmatic… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 57 references

TGF-beta-induces epithelial– mesenchymal-transition in primary human bronchial epithelial cells from normal and asthmatic subjects [abstract

T-L Hackett, SM Warner, +6 authors DA. Knight
Am J Respir Crit Care Med 2008;177:A97 • 2008
View 1 Excerpt

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