Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.

@article{Greenhalgh1993InductionOE,
  title={Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.},
  author={David A. Greenhalgh and Joseph A. Rothnagel and MODELJ. Quintanilla and C C Orengo and T A Gagne and Donnie Bundman and Mary Ann Longley and Dennis R. Roop},
  journal={Molecular carcinogenesis},
  year={1993},
  volume={7 2},
  pages={99-110}
}
The regulatory elements of the human keratin K1 gene have been used to target expression of the v-Ha-ras oncogene exclusively in the epidermis of transgenic mice. We developed 12 transgenic mouse lines that express the HK1.ras transgene, producing epidermal hyperplasia in neonates and hyperkeratosis in juveniles. Eventually this skin phenotype diminished but with time adult animals developed papillomas that could persist or regress. The rate and frequency of tumorigenesis appeared to be limited… CONTINUE READING

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