Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation.

  title={Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation.},
  author={Ji Young Lee and Jeong Hwan Je and Kyung Jin Jung and Byung Pal Yu and Hae Young Chung},
  journal={Free radical biology & medicine},
  volume={37 4},
Lipid peroxidation and its end-product, 4-hydroxyhexenal (HHE), are known to affect redox balance during aging, which causes various degenerative processes including vascular alterations from endothelial cell deterioration. To better understand the molecular action of HHE in the development of vascular abnormalities during the aging process, we investigated whether the upregulation of inducible endothelial nitric oxide synthase (iNOS) by HHE is mediated through nuclear factor kappaB (NF-kappaB… CONTINUE READING
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