Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid

@article{Ching2002InductionOE,
  title={Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid},
  author={L. M. Ching and Zhixing Cao and Claudine Kieda and Sahar Zwain and Michael B Jameson and B. C. Baguley},
  journal={British Journal of Cancer},
  year={2002},
  volume={86},
  pages={1937 - 1942}
}
5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic acid induced dose-dependent apoptosis in vitro in HECPP murine endothelial cells in the absence of up-regulation of mRNA for tumour necrosis factor. Selective apoptosis of… CONTINUE READING
43 Citations
29 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

  • MB Jameson, PI Thompson, +5 authors P Kestell
  • Proc Am Soc Clin Oncol
  • 2000
Highly Influential
6 Excerpts

Poten - tial antitumor agents . 61 . Structure - activity relationships for in vivo colon 38 activity among disubstituted 9 - oxo - 9 H - xanthene - 4 - acetic acids

  • GW Rewcastle, GJ Atwell, L Zhuang, BC Baguley, WA Denny
  • J Med Chem
  • 1991
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…