Induction of endometriosis in mice: a new model sensitive to estrogen.

  title={Induction of endometriosis in mice: a new model sensitive to estrogen.},
  author={A. Cummings and J. L. Metcalf},
  journal={Reproductive toxicology},
  volume={9 3},
  • A. Cummings, J. L. Metcalf
  • Published 1995
  • Medicine
  • Reproductive toxicology
  • Endometriosis consists of the growth of endometrial tissue outside the uterus. A rat model of endometriosis is available to evaluate the potential for environmental chemicals to promote the disease but may be relatively insensitive for the evaluation of the hazard of certain compounds. Our objective, which was to develop a mouse model for endometriosis, was based on (a) the promotion of endometriosis in primates by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), (b) the apparent relationship… CONTINUE READING
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