Induction of endochondral bone formation by recombinant human transforming growth factor-beta2 in the baboon (Papio ursinus).

@article{Ripamonti2000InductionOE,
  title={Induction of endochondral bone formation by recombinant human transforming growth factor-beta2 in the baboon (Papio ursinus).},
  author={Ugo Ripamonti and J. B. Crooks and Thato N Matsaba and Jeffrey Tasker},
  journal={Growth factors},
  year={2000},
  volume={17 4},
  pages={269-85}
}
Members of the transforming growth factor-beta (TGF-beta) superfamily, the bone morphogenetic and osteogenic proteins (BMPs/OPs) but not the TGF-beta proteins themselves, induce endochondral bone formation in vivo, when implanted in extraskeletal heterotopic sites of rodents. Here we show that recombinant human TGF-beta2 (hTGF-beta2) induces endochondral bone formation 30 days after implantation in heterotopic intramuscular sites of the baboon (Papio ursinus) at doses of 1, 5 and 25 microg per… CONTINUE READING