Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.

@article{Halder1995InductionOE,
  title={Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.},
  author={G. Halder and P. Callaerts and W. Gehring},
  journal={Science},
  year={1995},
  volume={267 5205},
  pages={
          1788-92
        }
}
  • G. Halder, P. Callaerts, W. Gehring
  • Published 1995
  • Biology, Medicine
  • Science
  • The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are expressed similarly in the developing nervous system and in the eye during morphogenesis. Loss-of-function mutations in both the insect and in the mammalian genes have been shown… CONTINUE READING
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