Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.

  title={Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.},
  author={G. Halder and P. Callaerts and W. Gehring},
  volume={267 5205},
  • G. Halder, P. Callaerts, W. Gehring
  • Published 1995
  • Biology, Medicine
  • Science
  • The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are expressed similarly in the developing nervous system and in the eye during morphogenesis. Loss-of-function mutations in both the insect and in the mammalian genes have been shown… CONTINUE READING
    1,494 Citations
    Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila.
    • 136
    • PDF
    Multiple roles of the eyes absent gene in Drosophila.
    • 112
    Expression of evolutionarily conserved eye specification genes during Drosophila embryogenesis
    • 45
    Functional divergence between eyeless and twin of eyeless in Drosophila melanogaster
    • 51
    • PDF
    Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies
    • 117
    • PDF


    Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans.
    • 1,040
    The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system
    • 517
    • Highly Influential
    The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development
    • 569
    • Highly Influential
    • PDF
    Transvection at the eyes absent gene of Drosophila.
    • 61
    • PDF
    Autoregulation of a drosophila homeotic selector gene
    • 198
    Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation.
    • N. Baker
    • Biology, Medicine
    • Development
    • 1988
    • 207
    • PDF
    Midline signalling is required for Pax gene regulation and patterning of the eyes.
    • 444
    • PDF
    Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development.
    • 460