Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle.

@article{Hjoberg2004InductionOE,
  title={Induction of early growth-response factor 1 by platelet-derived growth factor in human airway smooth muscle.},
  author={Josephine Hjoberg and Louis Le and Amy Imrich and Venkat Subramaniam and Sheeba I Mathew and Joseph C Vallone and Kathleen J. Haley and Francis H Y Green and Stephanie A. Shore and Eric S. Silverman},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={286 4},
  pages={L817-25}
}
Platelet-derived growth factors (PDGF) may contribute to the activation and growth of smooth muscle that is characteristic of airway remodeling in asthmatic patients. Early growth response 1 (EGR-1) is a transcription factor that is induced in several cell types by PDGF and may mediate some of the effects of PDGF. We show that human airway smooth muscle cells in cell culture express EGR-1 1 h after addition of PDGF. Analysis of the EGR-1 promoter indicates that a serum response element located… CONTINUE READING