Induction of drug-metabolizing enzymes by xenobiotics.

  title={Induction of drug-metabolizing enzymes by xenobiotics.},
  author={Karl Walter Bock and Hans Peter Lipp and Barbara S. Bock-Hennig},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={20 11},
1. Isozymes of the cytochromes P-450, UDP-glucuronosyl transferases (UDPGT) and glutathione S-transferases appear to be differentially inducible by prototype inducers, such as 3-methylcholanthrene (MC), phenobarbital, pregnenolone 16 alpha-carbonitrile and clofibrate. 2. Mechanisms of induction include both transcriptional and post-transcriptional control. MC-type inducers (representing a large number of planar polycyclic aromatics, beta-naphthoflavone and polyhalogenated aromatics) bind with… CONTINUE READING
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