Induction of drug metabolism: the role of nuclear receptors.

@article{Handschin2003InductionOD,
  title={Induction of drug metabolism: the role of nuclear receptors.},
  author={C. Handschin and U. Meyer},
  journal={Pharmacological reviews},
  year={2003},
  volume={55 4},
  pages={
          649-73
        }
}
Induction of drug metabolism was described more than 40 years ago. Progress in understanding the molecular mechanism of induction of drug-metabolizing enzymes was made recently when the important roles of the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), two members of the nuclear receptor superfamily of transcription factors, were discovered to act as sensors for lipophilic xenobiotics, including drugs. CAR and PXR bind as heterodimeric complexes with the retinoid X… Expand
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