Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans.

@article{Fuhr2000InductionOD,
  title={Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans.},
  author={Uwe Fuhr},
  journal={Clinical pharmacokinetics},
  year={2000},
  volume={38 6},
  pages={493-504}
}
  • Uwe Fuhr
  • Published 2000 in Clinical pharmacokinetics
Currently, 5 different main mechanisms of induction are distinguished for drug-metabolising enzymes. The ethanol type of induction is mediated by ligand stabilisation of the enzyme, but the others appear to be mediated by intracellular 'receptors'. These are the aryl hydrocarbon (Ah) receptor, the peroxisome proliferator activated receptor (PPAR), the constitutive androstane receptor (CAR, phenobarbital induction) and the pregnane X receptor [PXR, rifampicin (rifampin) induction]. Enzyme… CONTINUE READING