Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase.

Abstract

The MAP kinase pathway inhibitor U0126 in combination with butyrate promotes differentiation in some colon cancer cell lines. We examined several inhibitors of histone deacetylase (HDAC) in combination with U0126 and other protein kinase inhibitors to see if these effects are general properties of HDAC inhibitors or butyrate alone. Alkaline phosphatase and… (More)

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@article{Lea2007InductionOD, title={Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase.}, author={Michael Anthony Lea and Chinwe Ibeh and Neel Lalit Shah and Mary Pat Moyer}, journal={Anticancer research}, year={2007}, volume={27 2}, pages={741-8} }