Induction of differentiation in human promyelocytic leukemia cell line HL60 by a new type of polyenes, falconensone A and its derivatives.

@article{Takahashi1998InductionOD,
  title={Induction of differentiation in human promyelocytic leukemia cell line HL60 by a new type of polyenes, falconensone A and its derivatives.},
  author={Noriko Takahashi and Akiyo Iwahori and Ken-ichi Kawai and Tetsuya Fukui},
  journal={Archives of biochemistry and biophysics},
  year={1998},
  volume={360 1},
  pages={
          113-20
        }
}
Falconensones A and B are new type of yellow pigment isolated from the mycelial extract of ascomycetous fungi, Emericella falconensis or Emericella fruticulosa, whose structures are similar to retinoic acid (RA). To date, biological activities of falconensones have not been reported. Herein, we reported that falconensone A inhibited growth of HL60 human leukemia cells, when used either singly or in combination with RA. Falconensone A alone did not induce differentiation of HL60 cells. However… 
Antitumor efficacy in vitro and in vivo of falconensones, a new type of polyene.
TLDR
Results indicate that falconensone A and its derivatives exhibit anticancer efficacy in a broad spectrum of cancer cell lines and may have great potential for clinical use in the treatment of various cancers.
[Induction of cell differentiation and development of new anticancer drugs].
  • N. Takahashi
  • Biology, Chemistry
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2002
TLDR
Screening of differentiation-inducing factors, such as purified aldehyde reductase, a xenobiotic metabolite enzyme, that induces differentiation of human acute myeloid leukemia HL60 cells into monocyte/macrophage cells is described, and mechanisms of all-trans-retinoic acid (RA)-induced differentiation are covered.
Acyclic Carotenoids and Their Oxidation Mixtures Inhibit the Growth of HL-60 Human Promyelocytic Leukemia Cells
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The results suggest that the acyclic carotenoids inhibit cell growth through apoptosis induction and that oxidation products of the carOTenoids participate in the growth inhibition.
Cytotoxicity effect of algal polysaccharides on HL60 cells
TLDR
New insights are provided into the cytotoxic action of polysaccharides on HL60 cells and the possible involvement of phosphatases in this process is suggested for the first time.
Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete.
TLDR
A stereaceous basidiomycete was investigated with regard to its capacity to produce yellow pigments after physical injury of the mycelium and demonstrated a polyketide backbone and that the introduction of the sole methyl branch is most likely S-adenosyl-l-methionine-dependent.
Cytotoxic synergy between indomethacin and hydrochloric acid in gastric mucosal cells.
TLDR
Given that the IC50 value of indomethacin for inhibition of prostaglandin synthesis is about 5 nM, the synergistic response between indomet hacin and hydrochloric acid appears to be independent of the inhibition of cyclooxygenase activity by indometHacin.
Calmodulin inhibitors from the fungus Emericella sp.
Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991
TLDR
Structures of 1–14 were elucidated on the basis of spectroscopic analysis and chemical evidence and showed moderate antibacterial activities against Bacillus subtilis.
Ecological-Friendly Pigments From Fungi
TLDR
The obstacle to the exploitation of new natural pigments sources is the food legislation, requesting costly toxicological research, manufacturing costs, and acceptance by consumers, which is likely to be the biggest impediment for expansion of the pigment list in the near future.

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