Induction of differentiation in human promyelocytic leukemia cell line HL60 by a new type of polyenes, falconensone A and its derivatives.

  title={Induction of differentiation in human promyelocytic leukemia cell line HL60 by a new type of polyenes, falconensone A and its derivatives.},
  author={Noriko Takahashi and Akiyo Iwahori and Ken-ichi Kawai and Tetsuya Fukui},
  journal={Archives of biochemistry and biophysics},
  volume={360 1},
Falconensones A and B are new type of yellow pigment isolated from the mycelial extract of ascomycetous fungi, Emericella falconensis or Emericella fruticulosa, whose structures are similar to retinoic acid (RA). To date, biological activities of falconensones have not been reported. Herein, we reported that falconensone A inhibited growth of HL60 human leukemia cells, when used either singly or in combination with RA. Falconensone A alone did not induce differentiation of HL60 cells. However… 
Antitumor efficacy in vitro and in vivo of falconensones, a new type of polyene.
Results indicate that falconensone A and its derivatives exhibit anticancer efficacy in a broad spectrum of cancer cell lines and may have great potential for clinical use in the treatment of various cancers.
[Induction of cell differentiation and development of new anticancer drugs].
  • N. Takahashi
  • Biology, Chemistry
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2002
Screening of differentiation-inducing factors, such as purified aldehyde reductase, a xenobiotic metabolite enzyme, that induces differentiation of human acute myeloid leukemia HL60 cells into monocyte/macrophage cells is described, and mechanisms of all-trans-retinoic acid (RA)-induced differentiation are covered.
Acyclic Carotenoids and Their Oxidation Mixtures Inhibit the Growth of HL-60 Human Promyelocytic Leukemia Cells
The results suggest that the acyclic carotenoids inhibit cell growth through apoptosis induction and that oxidation products of the carOTenoids participate in the growth inhibition.
Cytotoxicity effect of algal polysaccharides on HL60 cells
New insights are provided into the cytotoxic action of polysaccharides on HL60 cells and the possible involvement of phosphatases in this process is suggested for the first time.
Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete.
A stereaceous basidiomycete was investigated with regard to its capacity to produce yellow pigments after physical injury of the mycelium and demonstrated a polyketide backbone and that the introduction of the sole methyl branch is most likely S-adenosyl-l-methionine-dependent.
Cytotoxic synergy between indomethacin and hydrochloric acid in gastric mucosal cells.
Given that the IC50 value of indomethacin for inhibition of prostaglandin synthesis is about 5 nM, the synergistic response between indomet hacin and hydrochloric acid appears to be independent of the inhibition of cyclooxygenase activity by indometHacin.
Calmodulin inhibitors from the fungus Emericella sp.
Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991
Structures of 1–14 were elucidated on the basis of spectroscopic analysis and chemical evidence and showed moderate antibacterial activities against Bacillus subtilis.
Ecological-Friendly Pigments From Fungi
The obstacle to the exploitation of new natural pigments sources is the food legislation, requesting costly toxicological research, manufacturing costs, and acceptance by consumers, which is likely to be the biggest impediment for expansion of the pigment list in the near future.


Retinoic acid treatment of acute promyelocytic leukemia: in vitro and in vivo observations.
It is suggested that oral retinoic acid may be a useful adjunct in the treatment of APL and induces maturation of leukemic promyelocytes in vitro and suggest that similar maturation is achievable in vivo.
Terminal Differentiation of Human Promyelocytic Leukemic Cells in Primary Culture in Response to Retinoic Acid
Because it appears that retinoic acid specifically induces granulocytic differentiation of leukemic promyelocytes, this compound may have therapeutic utility in the treatment of acute Promyelocytic leukemia.
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia.
All-trans retinoic acid is an effective inducer for attaining complete remission in APL and no abnormalities in the coagulation parameters were measured, suggesting an absence of any subclinical disseminated intravascular coagulations.
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
Tretinoin is a safe and highly effective agent for inducing complete remission in patients with acute promyelocytic leukemia and clinical response to this agent is associated with leukemic-cell differentiation and is linked to the expression of an aberrant RAR-alpha nuclear receptor.
The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias.
Analysis of the structure and expression of retinoic acid receptor (RAR) genes in 16 M3 patients suggests that alteration of the RAR alpha gene may be implicated in M3 leukemogenesis.
N-(4-hydroxyphenyl)retinamide (Fenretinide) in combination with retinoic acid enhances differentiation and retinoylation of proteins.
4-HPR may be a member of a class of retinoids that are active because they displace RA from extracellular and intracellular sites or because they inhibit RA catabolism, and may have utility in the clinic in combination with RA.
The role of 13 cis‐retinoic acid in the remission induction of a patient with acute promyelocytic leukemia
The addition of retinoic acid to human promyelocytic leukemia cells in culture results in their differentiation to mature myeloid forms with acquisition of the differentiated phenotype, i.e., the
A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients.
It is suggested that RA should be replaced by conventional chemotherapy as soon as CR is achieved, and the sensitivity of newly emerged leukemic clones to RA was greatly reduced.
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
The derivation from myeloid leukaemic cells of a leukocyte culture is described here for the first time that by morphological and histochemical criteria clearly and persistently differentiates along the myeloids series without an exogenous source of conditioned medium.