Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin.

@article{Tal2004InductionOD,
  title={Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin.},
  author={Michael G. Tal and Boaz Hirshberg and Ziv Neeman and David B. Bunnell and S. Soleimanpour and John Bach{\'e}r and Noelle Patterson and Richard Chang and David M Harlan},
  journal={Radiology},
  year={2004},
  volume={230 1},
  pages={163-8}
}
PURPOSE To develop and assess a technique for induction of C peptide-negative diabetes in adult nonhuman primates in preparation for preclinical investigation of type 1 diabetes treatments. MATERIALS AND METHODS First, temporary embolization of the hepatic and gastric arteries was performed in 14 adult nonhuman primates (six cynomolgus, five rhesus, and three pigtail macaques). After embolization was confirmed with angiography, streptozotocin was injected at a dose of 50-70 mg/kg into the… CONTINUE READING

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