Induction of dental pulp-derived induced pluripotent stem cells in the absence of c-Myc for differentiation into neuron-like cells.

@article{Chang2014InductionOD,
  title={Induction of dental pulp-derived induced pluripotent stem cells in the absence of c-Myc for differentiation into neuron-like cells.},
  author={Yun-Ching Chang and Wan-chun Li and N -F Twu and Hsin-Yang Li and Wen-liang Lo and Yuh-Lih Chang and Y F Lee and Chun-Fu Lin and Yang-Hsin Shih and Ming-Teh Chen},
  journal={Journal of the Chinese Medical Association : JCMA},
  year={2014},
  volume={77 12},
  pages={618-25}
}
BACKGROUND A recent research breakthrough has demonstrated that the ectopic expression of four genes is sufficient to reprogram human fibroblasts into inducible pluripotent stem cells (iPSCs). However, whether human dental pulp cells (DPCs) could be reprogrammed into iPSCs remains an open question. In this study, we demonstrated that DPCs from deciduous and permanent teeth can be reprogrammed into iPSCs without c-Myc and had the capacity to differentiate into neuron-like cells. METHODS DPCs… CONTINUE READING
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