Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells.

@article{Taranger2005InductionOD,
  title={Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells.},
  author={Christel K. Taranger and A. Saifuddin. Noer and Anita L. S\orensen and Anne-Mari H{\aa}kelien and Andrew C. Boquest and Philippe Collas},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 12},
  pages={
          5719-35
        }
}
Functional reprogramming of a differentiated cell toward pluripotency may have long-term applications in regenerative medicine. We report the induction of dedifferentiation, associated with genomewide programming of gene expression and epigenetic reprogramming of an embryonic gene, in epithelial 293T cells treated with an extract of undifferentiated human NCCIT carcinoma cells. 293T cells exposed for 1 h to extract of NCCIT cells, but not of 293T or Jurkat T-cells, form defined colonies that… CONTINUE READING
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