Induction of cytotoxicity by chlorogenic acid in human oral tumor cell lines.

@article{Jiang2000InductionOC,
  title={Induction of cytotoxicity by chlorogenic acid in human oral tumor cell lines.},
  author={Yi Jiang and Kaoru Kusama and Kazue Satoh and Eiji Takayama and Shigenori Watanabe and Hiroshi Sakagami},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2000},
  volume={7 6},
  pages={483-91}
}
Millimolar concentrations of chlorogenic acid (CGA) showed higher cytotoxic activity against human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines, as compared with that against human gingival fibroblast (HGF). The cytotoxic activity of CGA was significantly reduced by catalase or CoCl2, but not affected by FeCl3 or CuCl2. ESR spectroscopy showed that higher (millimolar) concentrations of CGA produced radicals under alkaline conditions, acting as a prooxidant… CONTINUE READING
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