Induction of cytotoxic lymphocyte subsets against leukemia by stimulation with AML blasts

@article{Lotzov1993InductionOC,
  title={Induction of cytotoxic lymphocyte subsets against leukemia by stimulation with AML blasts},
  author={Eva Lotzov{\'a} and Cherylyn A. Savary},
  journal={Medical Oncology and Tumor Pharmacotherapy},
  year={1993},
  volume={10},
  pages={13-19}
}
Although the application of interleukin-2 (IL-2) activated lymphocytes in immunotherapy of acute myelogenous leukemia (AML) is of therapeutic interest, the high resistance of AML blasts to lymphocyte iysis may represent an obstacle to this type of therapy. However, our data shows that the leukemia resistance can be conquered by concomitant culture of lymphocytes with IL-2 and AML blasts. This approach induces not only leukemia-dlrected cytotoxic cells, but also promotes their growth… CONTINUE READING