Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.

Abstract

Striated muscle is the predominant site of gene expression after i.m. immunization of plasmid DNA, but it is not clear if myocytes or professional antigen-presenting cells (APCs) of hematopoietic origin present the encoded antigens to class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL). To address this issue, CTL… (More)

Topics

Cite this paper

@article{Doe1996InductionOC, title={Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.}, author={Barbara Doe and Martin J. Selby and S Wienand Barnett and J C Baenziger and Christopher M Walker}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1996}, volume={93 16}, pages={8578-83} }