Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes.

@article{Ciernik1996InductionOC,
  title={Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes.},
  author={I. Frank Ciernik and Jay A. Berzofsky and David P Carbone},
  journal={Journal of immunology},
  year={1996},
  volume={156 7},
  pages={
          2369-75
        }
}
Delivery of genetic expression constructs into living animals can effectively induce both humoral and cellular immunity to the expressed proteins. Here we test the effectiveness of genetic immunization with a minigene coding for single epitopes derived from mutant p53 or from HIV gp120. We show that when these constructs are delivered by particle bombardment-mediated DNA transfer into the skin of mice, it results in efficient induction of tumor protective CTL. The immunogenicity of the epitope… CONTINUE READING

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