Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate

@article{Wintersberger2004InductionOC,
  title={Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate},
  author={U. Wintersberger and J. Hirsch},
  journal={Molecular and General Genetics MGG},
  year={2004},
  volume={126},
  pages={61-70}
}
SummaryThe folic acid analogue, methotrexate, was found to be an effective inducer of the cytoplasmic petite mutation in different strains of S. carlsbergensis and S. cerevisiae. The induction varies considerably from strain to strain and also with growth conditions under which the experiments are carried out. Determination of mitochondrial protein synthesis in the presence of methotrexate shows a considerable decrease in incorporation of radioactive leucine before any significant induction of… Expand

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