Induction of cytokines and cytotoxicity against tumor cells by Newcastle disease virus.

@article{Zorn1994InductionOC,
  title={Induction of cytokines and cytotoxicity against tumor cells by Newcastle disease virus.},
  author={Ulrich Zorn and Iris Dallmann and Jirka Grosse and Holger Kirchner and Hubert Poliwoda and Jens Atzpodien},
  journal={Cancer biotherapy},
  year={1994},
  volume={9 3},
  pages={225-35}
}
The use of NDV as biological adjuvant in vaccines against human cancer is still actual in several clinical treatment protocols. In this study, we have investigated in vitro-effects of Newcastle disease virus (NDV) strain 73-T on isolated mononuclear blood cells and cultured tumor cells. Cellular cytotoxicity of PBMC freshly isolated from healthy donors against tumor cells was enhanced significantly (p < 0.01) after coincubation of NDV with effector cells. NDV failed to enhance cytotoxicity of… CONTINUE READING

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