Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid (CSF) during experimental bacterial meningitis.

@article{Bakhiet1998InductionOC,
  title={Induction of cytokines and anti-cytokine autoantibodies in cerebrospinal fluid (CSF) during experimental bacterial meningitis.},
  author={Moiz Bakhiet and Mona Mustafa and Jinping Zhu and Robert Harris and Lars Lindquist and Hans Link and Adi Diab},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={114 3},
  pages={398-402}
}
We have recently described the induction of anti-cytokine autoantibodies (Aabs) in the serum as a novel mechanism for cytokine regulation during bacterial infections. Here we use the infant rat-model of Haemophilus influenzae type b (Hib) meningitis to examine the induction of five potentially important cytokines and their autoantibody responses in the CSF. Protein levels of the cytokines interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), transforming growth factor-beta… CONTINUE READING