Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression

@article{Bauer1995InductionOC,
  title={Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression},
  author={Joachim Bauer and Fritz Hohagen and Evi Gimmel and Friederike Bruns and Stephanie Lis and Stephan Krieger and Wolfgang Ambach and Angela Guthmann and Heinz Grunze and Rosemarie Fritsch-Montero and Alexandra Weissbach and Ursula Ganter and Ulrich Frommberger and Dieter Riemann and Mathias Berger},
  journal={Biological Psychiatry},
  year={1995},
  volume={38},
  pages={611-621}
}

Experimental Immunomodulation, Sleep, and Sleepiness in Humans

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Preliminary evidence from human studies suggesting that inflammatory cytokines such as TNF‐α not only mediate altered sleep‐wake behavior during infections, but in addition are involved in physiological sleep regulation and in hypnotic effects of established sedating drugs.

Cytokine-associated emotional and cognitive disturbances in humans.

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In humans, a mild stimulation of the primary host defense has negative effects on emotional and memory functions, which is probably caused by cytokine release, and cytokines represent a novel target for neuropsychopharmacological research.

Cytokines, stress, and depression. Conclusions and perspectives.

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From the data that are reviewed in this volume, several important points emerge: cytokines administered to patients and laboratory animals induce symptoms of depression, and antidepressants have anti-inflammatory properties and attenuate the behavioral effects of immune challenge.

Cytokines, "depression due to a general medical condition," and antidepressant drugs.

TLDR
It is argued that immune activation is involved in the etiology and symptomatology of depression associated with various medical conditions.

REVIEW ARTICLE: Sleep and cytokine–immune functions in medical, psychiatric and primary sleep disorders

TLDR
Sleep disturbances accompany the fatigue and malaise in such chronic autoimmune diseases as rheumatoid arthritis, systemic lupus erythematosis and multiple sclerosis and may have implications for changes in sleep and increased IL-6 and TNF-α in the blood of patients with narcolepsy.

Dose-dependent effects of endotoxin on human sleep.

TLDR
Whereas it is well established that the endocrine and thermoregulatory systems are very sensitive to endotoxin, this study shows that human sleep-wake behavior is even more sensitive to activation of host defense mechanisms.

Brain-immune interactions in sleep.

Cytokines and serotonin transporter in patients with major depression

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