Induction of cytogenetic damage in human lymphocytes in vitro and of antineoplastic effects in Ehrlich ascites tumor cells in vivo treated by methotrexate, hyperthermia and/or caffeine.

@article{Maskaleris1998InductionOC,
  title={Induction of cytogenetic damage in human lymphocytes in vitro and of antineoplastic effects in Ehrlich ascites tumor cells in vivo treated by methotrexate, hyperthermia and/or caffeine.},
  author={T. Maskaleris and T. Lialiaris and C. Triantaphyllidis},
  journal={Mutation research},
  year={1998},
  volume={422 2},
  pages={
          229-36
        }
}
The synergistic effect of methotrexate (at concentrations between 3. 1 and 100 nM) and its combinations with caffeine (618 microM) and/or hyperthermia (42 degreesC for 2 h) on the frequency of sister chromatid exchanges (SCEs), the proliferating rate index and the mitotic index in cultured human lymphocytes, was examined. Also, the in vivo antineoplastic effects of methotrexate (at a concentration of 0.45 microg/g body weight) and its combination with caffeine (120 microg/g body weight), both… Expand
Potentiation by caffeine of cytogenetic damage induced by steroidal derivatives in human lymphocytes in vitro.
Chromosome instability in patients with chronic renal failure.
Cytoprotective activity of amifostine on cultured human lymphocytes exposed to irinotecan.
  • T. Lialiaris, E. Kotsiou, +5 authors M. Koukourakis
  • Medicine, Chemistry
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
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