Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254.

@article{Lubet1991InductionOC,
  title={Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254.},
  author={Ronald A. Lubet and Claude Jones and D L Stockus and Stephen D. Fox and Raymond W. Nims},
  journal={Toxicology and applied pharmacology},
  year={1991},
  volume={108 2},
  pages={355-65}
}
Selected drug metabolizing activities were measured in female F344/NCr rats exposed to graded dietary concentrations of Aroclor 1254 (1 to 1000 ppm) for 7 days or to lower concentrations of Aroclor (1 to 10 ppm) for up to 28 days. Following the 7-day exposure, the hepatic O-dealkylation of ethoxyresorufin (ETR), mediated primarily by cytochrome P450IA, was… CONTINUE READING