Induction of cytochrome P-450 and an immune response by phenobarbital, free and covalently bound with albumin

Abstract

Definite interaction exists between the induction of microsomal enzymes and induction of the immune response to foreign substances. The loss by phenobarbital of its ability to induce the cytochrome P-450-hydroxylase system when bound covalently with albumin, coupled with the acquisition by phenobarbital of ability to induce a lymphocytic immune system reflects the ability of the two defensive systems of the body — hydroxylase and immune — to interact with foreign compounds of low and high molecular weight. The cytochrome P-450-hydroxylase system of the liver and other tissues is designed to protect the body against the action of low-molecular-weight hydrophobic compounds. The immune system is responsible for the protective effect against high-molecular-weight foreign substances.

DOI: 10.1007/BF00834241

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Cite this paper

@article{Archakov2004InductionOC, title={Induction of cytochrome P-450 and an immune response by phenobarbital, free and covalently bound with albumin}, author={Alexander I. Archakov and Irina I. Karuzina and D. {\'E}. Mengazetdinov and I. E. Kovalev and N. V. Astashkina and O. Yu. Polevaya and N. P. Danilova}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={89}, pages={325-327} }