Induction of cyclooxygenase-2 in the brain by cytokines.

@article{Cao1997InductionOC,
  title={Induction of cyclooxygenase-2 in the brain by cytokines.},
  author={Chunlin Cao and Kozaburo Matsumura and Yumi Watanabe},
  journal={Annals of the New York Academy of Sciences},
  year={1997},
  volume={813},
  pages={
          307-9
        }
}
The present study revealed that (1) a pyrogenic dose of IL-1 beta induced COX-2 mRNA in the brain vasculature and leptomeninges, and (2) the cells positive for COX-2 mRNA in the blood vessels were endothelial cells that possess receptors for IL-1. These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever. In this sense, the endothelial… CONTINUE READING
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